Allen J M, Williams G, O'Shea J P, Smith C, Yeo T, Kerle D, Bloom S R
Urol Res. 1984;12(5):249-51. doi: 10.1007/BF00256149.
Serum concentrations of gonadotropins, testosterone and dehydrotestosterone were determined in patients receiving conventional endocrine therapy for advanced metastatic adenocarcinoma of prostate. The effect over 4 h of a single dose of a long acting analogue of LHRH was determined in these patients and compared to the response in patients receiving the analogues as first choice of treatment. Oestrogen therapy was found to suppress basal and stimulated gonadotropins and testicular androgens. Cyproterone therapy only partially reduced basal hormone concentrations and the response to the LHRH analogue was delayed. Orchidectomy resulted in elevated gonadotropins and an exaggerated response to the analogue. As patients who relapse while failing conventional therapy, may subsequently be treated by further endocrine manipulation, precise determination of their endocrine status should predict any expected benefit. Patients previously treated with stilboestrol are unlikely to respond to orchidectomy or LHRH analogue.
对接受晚期转移性前列腺腺癌常规内分泌治疗的患者测定了促性腺激素、睾酮和脱氢睾酮的血清浓度。在这些患者中测定了单剂量长效促黄体生成素释放激素（LHRH）类似物4小时的效果，并与将该类似物作为首选治疗的患者的反应进行了比较。发现雌激素治疗可抑制基础和刺激状态下的促性腺激素以及睾丸雄激素。环丙孕酮治疗仅部分降低基础激素浓度，且对LHRH类似物的反应延迟。睾丸切除术导致促性腺激素升高以及对该类似物的反应过度。由于在常规治疗失败后复发的患者可能随后接受进一步的内分泌干预，精确测定其内分泌状态应能预测任何预期获益。先前接受己烯雌酚治疗的患者不太可能对睾丸切除术或LHRH类似物产生反应。
