• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Activation of 5'-deoxy-5-fluorouridine by thymidine phosphorylase in human tumors.

作者信息

Kono A, Hara Y, Sugata S, Karube Y, Matsushima Y, Ishitsuka H

出版信息

Chem Pharm Bull (Tokyo). 1983 Jan;31(1):175-8. doi: 10.1248/cpb.31.175.

DOI:10.1248/cpb.31.175
PMID:6221809
Abstract
摘要

相似文献

1
Activation of 5'-deoxy-5-fluorouridine by thymidine phosphorylase in human tumors.
Chem Pharm Bull (Tokyo). 1983 Jan;31(1):175-8. doi: 10.1248/cpb.31.175.
2
[5'-Deoxy-5-fluorouridine and 5-fluorouracil concentrations and thymidine phosphorylase activity in brain tumors following intravenous administration of 5'-deoxy-5-fluorouridine].静脉注射5'-脱氧-5-氟尿苷后脑肿瘤中5'-脱氧-5-氟尿苷和5-氟尿嘧啶浓度及胸苷磷酸化酶活性
Neurol Med Chir (Tokyo). 1985 Aug;25(8):613-9. doi: 10.2176/nmc.25.613.
3
Role of uridine phosphorylase for antitumor activity of 5'-deoxy-5-fluorouridine.尿苷磷酸化酶在5'-脱氧-5-氟尿苷抗肿瘤活性中的作用。
Gan. 1980 Feb;71(1):112-23.
4
[5'-Deoxy-5-fluorouridine enzymatic activation from the masked compound to 5-fluorouracil in human malignant tissues].
Gan To Kagaku Ryoho. 1984 Oct;11(10):2133-43.
5
[Correlation between pyrimidine nucleoside phosphorylase (PyNPase)/thymidine phosphorylase/platelet-derived endothelial cell growth factor and histological prognostic factor, and influence of 5'-deoxy-5-fluorouridine (5'-DFUR) administration on PyNPase activities and serum immunosuppressive acidic protein levels. A study group of oral anti-cancer drugs in Seiban/Tajima area].[嘧啶核苷磷酸化酶(PyNPase)/胸苷磷酸化酶/血小板衍生内皮细胞生长因子与组织学预后因素的相关性,以及5'-脱氧-5-氟尿苷(5'-DFUR)给药对PyNPase活性和血清免疫抑制酸性蛋白水平的影响。濑班/田岛地区口服抗癌药物研究组]
Gan To Kagaku Ryoho. 1998 Feb;25(3):359-64.
6
[Doxifluridine for treatment of colorectal cancer].[多西氟尿苷用于治疗结直肠癌]
Nihon Rinsho. 2003 Sep;61 Suppl 7:345-8.
7
Enzyme-prodrug systems: thymidine phosphorylase/5'-deoxy-5-fluorouridine.酶-前药系统:胸苷磷酸化酶/5'-脱氧-5-氟尿苷
Methods Mol Med. 2004;90:263-78. doi: 10.1385/1-59259-429-8:263.
8
The degradation of 5'-deoxy-5-fluorouridine by pyrimidine nucleoside phosphorylase in normal and cancer tissues.
Clin Chim Acta. 1985 Jul 15;149(2-3):175-83. doi: 10.1016/0009-8981(85)90331-6.
9
Specificity of pyrimidine nucleoside phosphorylases and the phosphorolysis of 5-fluoro-2'-deoxyuridine.嘧啶核苷磷酸化酶的特异性及5-氟-2'-脱氧尿苷的磷酸解作用
Cancer Res. 1980 Mar;40(3):507-11.
10
A simple and convenient assay method for phosphorolysis of 5'-deoxy-5-fluorouridine.
Gan. 1981 Dec;72(6):965-8.

引用本文的文献

1
Impact of ERCC1 on the outcomes of chemotherapy in advanced biliary tract cancer.
Sci Rep. 2025 Sep 30;15(1):33862. doi: 10.1038/s41598-025-07058-7.
2
Effects of six pyrimidine analogs on the growth of Tetrahymena thermophila and their implications in pyrimidine metabolism.六种嘧啶类似物对嗜热四膜虫生长的影响及其对嘧啶代谢的意义。
PLoS One. 2023 Sep 14;18(9):e0284309. doi: 10.1371/journal.pone.0284309. eCollection 2023.
3
Advanced prodrug strategies in nucleoside analogues targeting the treatment of gastrointestinal malignancies.靶向胃肠道恶性肿瘤治疗的核苷类似物中的先进前药策略。
Front Cell Dev Biol. 2023 Apr 18;11:1173432. doi: 10.3389/fcell.2023.1173432. eCollection 2023.
4
Enhanced Tumor Selectivity of 5-Fluorouracil Using a Reactive Oxygen Species-Activated Prodrug Approach.使用活性氧激活前药方法增强5-氟尿嘧啶的肿瘤选择性
ACS Med Chem Lett. 2018 Dec 3;10(1):127-131. doi: 10.1021/acsmedchemlett.8b00539. eCollection 2019 Jan 10.
5
The evolution of antiviral nucleoside analogues: A review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold.抗病毒核苷类似物的进化:化学家和非化学家的综述。第二部分:核苷骨架的复杂修饰。
Antiviral Res. 2019 Feb;162:5-21. doi: 10.1016/j.antiviral.2018.11.016. Epub 2018 Dec 8.
6
Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs.抗癌核苷、核苷酸及碱基类似物的代谢、生化作用和化学合成
Chem Rev. 2016 Dec 14;116(23):14379-14455. doi: 10.1021/acs.chemrev.6b00209. Epub 2016 Nov 23.
7
Effect of age on the disposition and tissue clearances of fluorinated pyrimidines in rats.年龄对氟嘧啶类药物在大鼠体内处置和组织清除率的影响。
Pharm Res. 1985 Nov;2(6):279-84. doi: 10.1023/A:1016389517202.
8
Impact of the new AJCC staging system and adjuvant treatment in rectal cancer.新 AJCC 分期系统和辅助治疗对直肠癌的影响。
Cancer Res Treat. 2004 Apr;36(2):121-7. doi: 10.4143/crt.2004.36.2.121. Epub 2004 Apr 30.
9
Phase I/II study of gefitinib and capecitabine in patients with colorectal cancer.吉非替尼与卡培他滨用于结直肠癌患者的I/II期研究。
Clin Transl Oncol. 2008 Jan;10(1):52-7. doi: 10.1007/s12094-008-0153-5.
10
Unresectable gastric cancer with multiple liver metastases effectively treated with combined paclitaxel and doxifluridine chemotherapy.多西他赛与去氧氟尿苷联合化疗有效治疗不可切除的伴有多发肝转移的胃癌。
Int J Clin Oncol. 2006 Dec;11(6):471-4. doi: 10.1007/s10147-006-0597-y. Epub 2006 Dec 25.