异丙醇和甲酸根自由基对生物活性DNA的灭活作用。
Inactivation of biologically active DNA by isopropanol and formate radicals.
作者信息
Nabben F J, van der Stroom H A, Loman H
出版信息
Int J Radiat Biol Relat Stud Phys Chem Med. 1983 May;43(5):495-504. doi: 10.1080/09553008314550591.
PMID:6222005
Abstract
If OH and H radicals, produced by absorption of ionizing radiation in aqueous solutions, are scavenged with isopropanol or sodium formate, secondary radicals are formed which can inactivate phi X174 DNA. From experiments at various DNA concentrations and dose rates we were able to determine the rate constant and the inactivation efficiency of the reaction of these organic radicals with single stranded DNA.
摘要
如果通过水溶液中电离辐射的吸收产生的OH和H自由基用异丙醇或甲酸钠清除，就会形成能使φX174 DNA失活的次级自由基。通过在不同DNA浓度和剂量率下进行的实验，我们能够确定这些有机自由基与单链DNA反应的速率常数和失活效率。
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