Presant C A, Ardalan B, Multhauf P, Chan C, Staples R, Green L, Browning S, Carr B I, Chang F F, Thayer W
Med Pediatr Oncol. 1983;11(3):162-3. doi: 10.1002/mpo.2950110305.
In order to determine whether a simultaneous infusion of N-(phospho-n-acetyl)-L-aspartic acid (PALA) was able to increase the rate of antitumor response to 5-fluorouracil (5-FU), a pilot study was conducted. Of 10 evaluable patients with previously drug-untreated colorectal carcinoma, there were only two partial responses, lasting 2.3 and 1.6 months. No partial responses were observed in three evaluable patients with soft tissue sarcomas. The dose-limiting toxicity was dermatitis. The simultaneous infusion of PALA and 5-FU is not likely to produce a high number of antitumor responses of long duration in patients with colorectal carcinoma.
为了确定同时输注N-（磷酸-n-乙酰基）-L-天冬氨酸（PALA）是否能够提高对5-氟尿嘧啶（5-FU）的抗肿瘤反应率，开展了一项初步研究。在10例先前未接受过药物治疗的可评估结直肠癌患者中，仅出现了2例部分缓解，持续时间分别为2.3个月和1.6个月。在3例可评估的软组织肉瘤患者中未观察到部分缓解。剂量限制性毒性为皮炎。同时输注PALA和5-FU不太可能在结直肠癌患者中产生大量持久的抗肿瘤反应。
