Seignalet J
Pathol Biol (Paris). 1983 Jan;31(1):53-9.
To explain the relations between Ia and Ir, we propose the following hypothesis. It would exist an antigen specific factor released by T lymphocytes. This factor would be constituted by two parts: a variable fragment forming the antigenic receptor of T cells and coded by Ir genes, a constant fragment transmitting an helper or suppressor signal and carrying Ia antigens. Ia antigens would allow a mutual recognition between macrophages, T lymphocytes and B lymphocytes and a recognition by these cells of some mediators released during immune response. Ir genes products would allow the antigen recognition, if they correspond to the antigenic receptor of T lymphocytes.
为了解释Ia和Ir之间的关系，我们提出以下假说。T淋巴细胞会释放一种抗原特异性因子。该因子由两部分组成：一个可变片段，构成T细胞的抗原受体并由Ir基因编码；一个恒定片段，传递辅助或抑制信号并携带Ia抗原。Ia抗原能使巨噬细胞、T淋巴细胞和B淋巴细胞之间相互识别，并使这些细胞识别免疫反应过程中释放的某些介质。如果Ir基因产物与T淋巴细胞的抗原受体相对应，它们就能实现抗原识别。
