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[亚美尼亚人群中多发性硬化症患者红细胞血型的遗传标记]

[Genetic markers of erythrocyte blood groups in multiple sclerosis among the Armenian population].

作者信息

Darbinian V Zh, Nersisian V M, Martirosian I G

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1983;83(3):42-6.

PMID:6222575
Abstract

The isoserologic systems, including AB, Rh-Hz, MNSs, Duffy, Kidd, Kell-Chellano, Lutheran, Diego, and Lewis ones were investigated in 50 patients with disseminated sclerosis and in the general population. An increased rate of the Duffy phenotype (a-b+) is reported in the patients versus the population control. Individuals with this phenotype are at three times as great a risk of developing disseminated sclerosis than those with the Duffy phenotype (a+b-). The Duffy antigen (b+) is considered as a possible genetic marker of the disease in the Armenian population.

摘要

在50例多发性硬化症患者和普通人群中,对包括AB、Rh-Hz、MNSs、达菲、基德、凯尔-切拉诺、路德、迭戈和刘易斯血型系统在内的同种血清学系统进行了研究。与人群对照组相比,患者中达菲血型表型(a-b+)的比例有所增加。具有这种表型的个体患多发性硬化症的风险是具有达菲血型表型(a+b-)个体的三倍。在亚美尼亚人群中,达菲抗原(b+)被认为是该疾病可能的遗传标志物。

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