Cheng Y C, Nakayama K, Grill S P
Biochem Pharmacol. 1983 Apr 15;32(8):1407-10. doi: 10.1016/0006-2952(83)90454-9.
Thymidylate synthetase was not essential for herpes simplex virus replication. However, it appeared to contribute to the formation of a portion of thymidine nucleotides for DNA synthesis in virus-infected cells. Therefore, it is possible that the enzyme plays an important role in determining the potency of several selective antiviral thymidine analogs. Since synergistic effects of 5-fluoro-2'-deoxyuridine with other analogs on virus reproduction were observed, it is suggested that the effects of these analogs depend to a certain degree on the abilities of the monophosphate derivatives to inhibit thymidylate synthetase.
胸苷酸合成酶对单纯疱疹病毒的复制并非必不可少。然而，它似乎有助于在病毒感染的细胞中形成一部分用于DNA合成的胸苷核苷酸。因此，该酶在确定几种选择性抗病毒胸苷类似物的效力方面可能起着重要作用。由于观察到5-氟-2'-脱氧尿苷与其他类似物对病毒繁殖具有协同作用，提示这些类似物的作用在一定程度上取决于单磷酸衍生物抑制胸苷酸合成酶的能力。
