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大鼠出生后早期发育过程中的骨骼肌脂肪酸氧化

Skeletal muscle fatty acid oxidation during early postnatal development in the rat.

作者信息

Carroll J E, Shumate J B, Villadiego A, Choksi R M, Morse D P

出版信息

Biol Neonate. 1983;43(3-4):191-7. doi: 10.1159/000241628.

DOI:10.1159/000241628
PMID:6222770
Abstract

(1-14C)-palmitate oxidation in rat skeletal muscle homogenates increased only minimally from birth until 15 days of age and then increased more than five times between 15 days and adulthood. In contrast, liver oxidation of palmitate reached adult levels by 4 days of age. Although muscle carnitine concentration, carnitine palmityl transferase activity, and total muscle protein increased during the neonatal period, these changes did not completely parallel the rise in muscle palmitate oxidation. Palmityl-CoA synthetase and palmityl-CoA dehydrogenase activities also did not parallel the rise in overall palmitate oxidation.

摘要

在大鼠骨骼肌匀浆中,(1-14C)-棕榈酸氧化从出生到15日龄仅略有增加,然后在15日龄至成年期之间增加了五倍多。相比之下,肝脏中棕榈酸氧化在4日龄时达到成年水平。尽管在新生儿期肌肉肉碱浓度、肉碱棕榈酰转移酶活性和肌肉总蛋白有所增加,但这些变化与肌肉棕榈酸氧化的升高并不完全平行。棕榈酰辅酶A合成酶和棕榈酰辅酶A脱氢酶的活性也与整体棕榈酸氧化的升高不平行。

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Skeletal muscle fatty acid oxidation during early postnatal development in the rat.大鼠出生后早期发育过程中的骨骼肌脂肪酸氧化
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