Feldman D S, Hultman S M, Colaizzo R S, von Recum A F
Biomaterials. 1983 Apr;4(2):105-11. doi: 10.1016/0142-9612(83)90049-2.
Electron microscopic and light microscopic analyses were performed on Dacron velour covered percutaneous devices implanted in the dorsum of canines for periods between 1 week and 9 months. The results indicated that although the capsular region around the implant was mature collagen after the 1st week of implantation, the tissue ingrowth region remained mostly immature collagen through 9 months of implantation. It appears that increasing the diameter of the fibres, which would decrease the chronic inflammatory response, and increasing the average distance between fibres should increase the amount of mature collagen between the velour fibres. In view of species differences between canines and humans, further investigations are needed before the relevancy of these findings can be extended to possible clinical applications with humans.
对植入犬背部达1周龄至9月龄的涤纶丝绒覆盖经皮装置进行了电子显微镜和光学显微镜分析。结果表明，虽然植入1周后植入物周围的包膜区域是成熟的胶原蛋白，但在植入9个月后组织向内生长区域大部分仍为未成熟的胶原蛋白。似乎增加纤维直径（这将减少慢性炎症反应）以及增加纤维之间的平均距离，应该会增加丝绒纤维之间成熟胶原蛋白的数量。鉴于犬类和人类之间的物种差异，在这些发现的相关性能够扩展到可能的人类临床应用之前，还需要进一步研究。
