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GANU及其他亚硝基脲衍生物对小鼠可移植性白血病和实体瘤的抗肿瘤作用。

Antitumor effects of GANU and other nitrosourea derivatives against transplantable leukemias and solid tumors in mice.

作者信息

Sava G, Giraldi T

出版信息

Cancer Chemother Pharmacol. 1983;10(3):167-9. doi: 10.1007/BF00255754.

DOI:10.1007/BF00255754
PMID:6222844
Abstract

The antitumor effects of GANU have been examined in a panel of mouse tumors for which data appear to be lacking in the literature. GANU has significant activity against P388 leukemia and TLX5 lymphoma, and also against the solid tumors B16 melanoma and Lewis lung carcinoma; pulmonary metastases of this tumor are particularly sensitive to the effects of GANU. The effects of GANU on TLX5 lymphoma and Lewis lung carcinoma are less pronounced than those of BCNU and CCNU, as already reported for L1210 leukemia. In contrast with other results obtained with this tumor, chlorozotocin has a less pronounced effect than GANU, and virtually none in lung metastases of Lewis lung carcinoma.

摘要

GANU的抗肿瘤作用已在一组小鼠肿瘤中进行了研究，而这些肿瘤的相关数据在文献中似乎尚无报道。GANU对P388白血病和TLX5淋巴瘤具有显著活性，对实体瘤B16黑色素瘤和Lewis肺癌也有活性；该肿瘤的肺转移对GANU的作用尤为敏感。正如之前关于L1210白血病的报道，GANU对TLX5淋巴瘤和Lewis肺癌的作用不如卡莫司汀和洛莫司汀明显。与该肿瘤的其他研究结果相反，氯脲霉素的作用不如GANU明显，在Lewis肺癌的肺转移中几乎没有作用。

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1
Antitumor effects of GANU and other nitrosourea derivatives against transplantable leukemias and solid tumors in mice.GANU及其他亚硝基脲衍生物对小鼠可移植性白血病和实体瘤的抗肿瘤作用。
Cancer Chemother Pharmacol. 1983;10(3):167-9. doi: 10.1007/BF00255754.
2
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引用本文的文献

1
CGP 6809, a sugar-containing nitrosourea derivative: pharmacological and physicochemical properties.
Cancer Chemother Pharmacol. 1989;23(6):341-7. doi: 10.1007/BF00435833.

本文引用的文献

1
Selectivity of the antimetastatic and cytotoxic effects of 1-p-(3,3-dimethyl-1-triazeno)benzoic acid potassium salt (+/-)-1,2-di(3,5-dioxopiperazin-1-yl)propane, and cyclophosphamide in mice bearing Lewis lung carcinoma.1-对-(3,3-二甲基-1-三氮烯)苯甲酸钾盐、(±)-1,2-二(3,5-二氧代哌嗪-1-基)丙烷和环磷酰胺对荷Lewis肺癌小鼠的抗转移和细胞毒性作用的选择性
Cancer Res. 1981 Jun;41(6):2524-8.
2
Comparison of antitumor activities of nitrosourea derivatives against mammary breast carcinoma (MX-1) in nude mice.亚硝基脲衍生物对裸鼠乳腺腺癌（MX-1）的抗肿瘤活性比较。
Gan. 1980 Oct;71(5):686-91.
3
Antitumor activity of N-diazoacetyl derivatives of glycine and phenylalanine against P388 leukemia and B16 melanoma in mice.
甘氨酸和苯丙氨酸的N-重氮乙酰基衍生物对小鼠P388白血病和B16黑色素瘤的抗肿瘤活性。
Cancer Treat Rep. 1982 Jan;66(1):179-81.
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Phase I study of GANU and MCNU.
Cancer Treat Rev. 1980 Dec;7(4):197-203. doi: 10.1016/s0305-7372(80)80036-3.
5
Combination chemotherapy of L1210 mouse leukemia using a new water-soluble nitrosourea, 1-(2-chloroethyl)-3-(beta-d-glucopyranosyl)-1-nitrosourea, with various antimetabolites.使用一种新型水溶性亚硝基脲1-(2-氯乙基)-3-(β-D-吡喃葡萄糖基)-1-亚硝基脲与多种抗代谢物联合治疗L1210小鼠白血病。
Gan. 1980 Aug;71(4):425-32.
6
Therapy of advanced gastrointestinal cancer with the nitrosoureas.亚硝基脲类药物治疗晚期胃肠道癌
Cancer Chemother Rep 3. 1973 May;4(3):27-34.
7
An overview of the status of the nitrosoureas in other tumors.亚硝基脲类药物在其他肿瘤中的应用现状综述。
Cancer Chemother Rep 3. 1973 May;4(3):35-46.
8
1,3-bis(2-chloroethyl)-1-nitrosourea (bcnu) and other nitrosoureas in cancer treatment: a review.
Adv Cancer Res. 1972;16:273-332. doi: 10.1016/s0065-230x(08)60343-7.
9
Comparative studies on the antitumor activity and the bone marrow toxicity of 1-(beta-D-glucopyranosyl)-3-(2-chloroethyl)-3-nitrosourea and 2-(3-(2-chloroethyl)-3-nitrosoureido)-D-glucopyranose.
Gan. 1977 Apr;68(2):247-50.
10
Preparation and antitumor activity of 1-aryl-3,3-dimethyltriazene derivatives.
J Med Chem. 1977 Jun;20(6):850-3. doi: 10.1021/jm00216a025.