Lieberman J S
Int Rehabil Med. 1982;4(4):195-9. doi: 10.3109/09638288209166917.
Extensive investigation of the role of the fusimotor system in the production of hypotonic and hypertonic disorders of posture and tone has been undertaken in humans and experimental animals. The data from human studies have usually been from indirect assessment of the fusimotor system, and results are often contradictory. Results are now available from animal studies utilizing direct recording of muscle spindle afferent discharge in a number of models of human disorder. Conditions resulting in hypotonia, e.g. cerebellar ablations, medullary pyramidotomy, VL nucleus, thalamotomy, acute spinal cord transection, and acute motor cortex ablation uniformly result in a depression of muscle spindle primary afferent discharge. Conditions resulting in hypertonia, e.g. chronic spinal cord transection and chronic motor cortex ablation, fail to show heightened muscle spindle afferent discharge, however. Rather the spindle afferent discharge returns to control levels in the models. Recovery from the hypotonic to the hypertonic state is, however, associated with significant recovery of spindle afferent function.
针对人类和实验动物，已经对肌梭运动系统在姿势和肌张力低张性及高张性障碍产生过程中的作用展开了广泛研究。来自人体研究的数据通常是对肌梭运动系统的间接评估，结果往往相互矛盾。现在已有来自动物研究的结果，这些研究在多种人类疾病模型中直接记录了肌梭传入放电情况。导致肌张力低下的情况，如小脑切除、延髓锥体束切断术、腹外侧核毁损术、丘脑切开术、急性脊髓横断和急性运动皮层切除，均一致导致肌梭初级传入放电减少。然而，导致肌张力亢进的情况，如慢性脊髓横断和慢性运动皮层切除，并未显示出肌梭传入放电增强。相反，在这些模型中，肌梭传入放电恢复到对照水平。不过，从低张状态恢复到高张状态与肌梭传入功能的显著恢复相关。
