Holzapfel L, Robert D, Gaussorgues P, Dumont C, Perrin F, Bertoye A
Presse Med. 1983 Jun 11;12(25):1581-6.
Sixteen adult patients with respiratory distress syndrome requiring mechanical respiratory assistance entered this study, the purpose of which was to obtain the same blood gas values under high frequency jet ventilation as under conventional ventilation. When high frequency jet ventilation without spontaneous breathing was compared to continuous positive pressure ventilation, peak airway pressure was the same, but mean airway pressure, positive end-expiratory pressure and pleural pressure were higher and cardiac index lower. When high frequency jet ventilation with spontaneous breathing was compared to intermittent mandatory ventilation, peak airway pressure was lower, mean airway pressure and positive end-expiratory pressure were higher, and pleural pressure and cardiac index were not different.
16名需要机械通气辅助的呼吸窘迫综合征成年患者进入本研究，其目的是在高频喷射通气下获得与传统通气相同的血气值。当将无自主呼吸的高频喷射通气与持续气道正压通气相比较时，气道峰压相同，但平均气道压、呼气末正压和胸膜腔内压更高，心脏指数更低。当将有自主呼吸的高频喷射通气与间歇指令通气相比较时，气道峰压更低，平均气道压和呼气末正压更高，胸膜腔内压和心脏指数无差异。
