Giudicelli C P, Nedelec G, Doulcet E, Falcot J, Girier L
Presse Med. 1983 Jun 11;12(25):1587-90.
The risk of renal damage from diphtheria, tetanus and typho-paratyphoid vaccination was assessed by means of a prospective and a retrospective study. The prospective study involved 817 young adults without history nor signs of urinary disease and therefore, with presumably healthy kidneys. Urine samples were taken before and after each injection and examined for proteinuria and microscopic haematuria. After a total of 1712 doses there was no evidence of post-vaccination nephropathy. In a retrospective study of 63 patients with various forms of glomerulonephritis vaccination was found to be responsible for one case of acute renal failure consecutive to proliferative lesions and one case of syndromic reaction in an asymptomatic Berger's disease. These two complementary studies show that post-vaccination nephropathy may occur, albeit rarely, and that current preventive measures should be pursued.
通过前瞻性和回顾性研究评估了白喉、破伤风和伤寒副伤寒疫苗接种导致肾损伤的风险。前瞻性研究纳入了817名无泌尿系统疾病病史及体征、因而推测肾脏健康的年轻成年人。每次注射前后采集尿样，检测蛋白尿和镜下血尿。在总共接种1712剂疫苗后，没有证据表明存在接种后肾病。在一项对63例各种类型肾小球肾炎患者的回顾性研究中，发现疫苗接种导致1例因增殖性病变继发的急性肾衰竭，以及1例无症状性伯杰氏病的综合征反应。这两项互补性研究表明，接种后肾病虽罕见但可能发生，当前的预防措施应继续推行。
