对氯苯丙氨酸（p-CPA）诱导大鼠脑内5-羟色胺耗竭及杀鼠攻击性的时间进程。

Time-courses of p-CPA-induced depletion of brain serotonin and muricidal aggression in the rat.

作者信息

Valzelli L, Bernasconi S, Dalessandro M

出版信息

Pharmacol Res Commun. 1983 Apr;15(4):387-95. doi: 10.1016/s0031-6989(83)80048-4.

Abstract

p-Chlorophenylalanine is known to selectively decrease brain serotonin and to induce muricidal aggression in previously docile rats. With regard to the substance's relatively time-limited effect on brain serotonergic system, the neurochemical activity of p-CPA on tryptophan, serotonin and 5-hydroxyindoleacetic acid on seven discrete areas of the rat brain is studied in parallel to the time-course of muricidal aggression induced by the drug. Evidence indicates that, following the disruption of brain serotonergic inhibitory control, muricidal aggression becomes a stable behavior, probably on account of its self-reinforcing property.

摘要

对氯苯丙氨酸已知能选择性降低脑内血清素，并在先前温顺的大鼠中诱发杀鼠攻击性。鉴于该物质对脑血清素能系统的作用相对有限，研究了对氯苯丙氨酸对大鼠脑七个离散区域中色氨酸、血清素和5-羟基吲哚乙酸的神经化学活性，并与该药物诱发的杀鼠攻击性的时间进程进行了平行研究。有证据表明，在脑血清素能抑制控制被破坏后，杀鼠攻击性可能由于其自我强化特性而成为一种稳定行为。