Malaisse W J, Malaisse-Lagae F, Sener A
Reprod Nutr Dev (1980). 1983;23(2 B):321-7. doi: 10.1051/rnd:19830301.
The alpha-anomers of D-glucose and D-mannose stimulate insulin release more efficiently than the corresponding beta-anomers. This coincides with higher glycolytic and oxidative fluxes in pancreatic islets exposed to alpha- than to beta-anomers. This situation may be attributable, in the case of alpha-D-glucose, not solely to the alpha-stereospecificity of phosphoglucose isomerase but also to that of phosphoglucomutase resulting in a higher islet content of glucose-1,6-bisphosphate, an activator of phosphofructokinase. Likewise, more aldohexose-bisphosphate accumulates in the islets exposed to alpha-D-mannose than in those incubated with beta-D-mannose. The anomeric specificity of hexose metabolism in pancreatic islets supports the fuel hypothesis for insulin release.
D-葡萄糖和D-甘露糖的α-异头物比相应的β-异头物更有效地刺激胰岛素释放。这与暴露于α-异头物的胰岛中比暴露于β-异头物的胰岛具有更高的糖酵解和氧化通量相吻合。就α-D-葡萄糖而言，这种情况可能不仅归因于磷酸葡萄糖异构酶的α-立体特异性，还归因于磷酸葡萄糖变位酶的α-立体特异性，从而导致胰岛中葡萄糖-1,6-二磷酸（磷酸果糖激酶的激活剂）含量更高。同样，暴露于α-D-甘露糖的胰岛中积累的醛己糖二磷酸比与β-D-甘露糖孵育的胰岛中更多。胰岛中己糖代谢的异头物特异性支持了胰岛素释放的燃料假说。
