Gibbs R S, Blanco J D, Duff P, Castaneda Y S, St Clair P J
Am J Obstet Gynecol. 1983 Aug 1;146(7):769-72. doi: 10.1016/0002-9378(83)91075-x.
A double-blind comparison of clindamycin plus gentamicin versus moxalactam plus placebo was performed for the treatment of endomyometritis after cesarean section delivery. Entry criteria were uterine tenderness, temperature greater than or equal to 101 degrees F, and leukocytosis. Uterine specimens were obtained for culture via a single-lumen transcervical catheter. Bacteremia occurred in 10% of patients. Among the 57 patients treated with clindamycin plus gentamicin, there were two clinical failures and four side effect failures (diarrhea in two, allergic reaction in two). Among the 56 patients in the moxalactam group, there were four clinical failures and one side effect failure (diarrhea). Both regimens had good cure rates, with no significant differences in cures or postoperative hospital stay.
对克林霉素加庆大霉素与莫西拉坦加安慰剂进行了双盲比较，以治疗剖宫产术后的子宫内膜炎。入选标准为子宫压痛、体温大于或等于101华氏度以及白细胞增多。通过单腔经宫颈导管获取子宫标本进行培养。10%的患者发生了菌血症。在57例接受克林霉素加庆大霉素治疗的患者中，有2例临床治疗失败和4例副作用失败（2例腹泻、2例过敏反应）。在莫西拉坦组的56例患者中，有4例临床治疗失败和1例副作用失败（腹泻）。两种治疗方案的治愈率都很高，在治愈率或术后住院时间方面没有显著差异。
