Taubman M A, Ebersole J L, Smith D J, Stack W
Ann N Y Acad Sci. 1983 Jun 30;409:637-49. doi: 10.1111/j.1749-6632.1983.tb26905.x.
Salivary IgA responses of rats receiving MDP were elevated after oral GTF administration and after infection with S. mutans bearing surface GTF. Intragastric administration (but not injection) of MDP enhanced salivary IgA responses to i.g. GTF. Subcutaneous injection (but not i.g. administration) of MDP enhanced IgA responses to GTF injected in the salivary gland vicinity. Conjugation of MDP to GTF did not enhance the secretory response to the antigen. Nevertheless, s.g.v. administration of OVA in IFA dramatically enhanced the secretory and serum responses. Injection of MDP may further enhance the secretory response. The combination of routes of adjuvant and antigen administration were critical in selectively enhancing a secretory immune response.
给予MDP的大鼠在口服GTF后以及感染携带表面GTF的变形链球菌后，其唾液IgA反应升高。胃内给予（而非注射）MDP可增强对口服GTF的唾液IgA反应。皮下注射（而非胃内给予）MDP可增强对注射于唾液腺附近的GTF的IgA反应。MDP与GTF结合并未增强对抗原的分泌反应。然而，在不完全弗氏佐剂中皮下注射OVA可显著增强分泌反应和血清反应。注射MDP可能会进一步增强分泌反应。佐剂和抗原给药途径的组合对于选择性增强分泌性免疫反应至关重要。
