组胺受体在肾素释放中的作用。
The role of histamine receptors in the release of renin.
作者信息
Gerber J G, Nies A S
出版信息
Br J Pharmacol. 1983 May;79(1):57-61. doi: 10.1111/j.1476-5381.1983.tb10495.x.
1 The effect of intrarenal histamine, dimaprit (H2-agonist) and 2-(2-pyridyl) ethylamine (H1-agonist) on renin release was examined in anaesthetized dogs. 2 In dogs with intact kidneys, histamine and dimaprit administration resulted in renal vasodilatation, a two fold increase in urinary sodium excretion, and no change in renal renin release. 2(2-Pyridyl) ethylamine administration resulted in renal vasodilatation, a 25% decrease in urinary sodium excretion and a significant increase in renin release. 3 In dogs with non-filtering kidneys, dimaprit administration resulted in renal vasodilatation and a significant increase in renin release, while 2(2-pyridyl) ethylamine administration resulted in renal vasodilatation but no change in renin release. 4 Our data suggest that histamine is a potential participant in the release of renin through stimulation of H2-receptors, but it is a weak agonist. 5 In addition, the direct effect of histamine analogues on renin release is modulated by their effects on electrolyte excretion probably by influencing the renal chemoreceptor release of renin mediated by the macula densa.
1 在麻醉犬中研究了肾内组胺、二甲双胍（H2 激动剂）和 2-(2-吡啶基)乙胺（H1 激动剂）对肾素释放的影响。2 在肾脏功能正常的犬中，给予组胺和二甲双胍导致肾血管舒张，尿钠排泄增加两倍，肾素释放无变化。给予 2-(2-吡啶基)乙胺导致肾血管舒张，尿钠排泄减少 25%，肾素释放显著增加。3 在无滤过功能肾脏的犬中，给予二甲双胍导致肾血管舒张，肾素释放显著增加，而给予 2-(2-吡啶基)乙胺导致肾血管舒张，但肾素释放无变化。4 我们的数据表明，组胺可能通过刺激 H2 受体参与肾素释放，但它是一种弱激动剂。5 此外，组胺类似物对肾素释放的直接作用可能通过影响致密斑介导的肾化学感受器肾素释放，进而受其对电解质排泄的影响而调节。
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