Capron M, Prin L, Tonnel A B, Capron A
Poumon Coeur. 1983;39(2):65-73.
The effector function of eosinophils is studied in experimental models, emphasizing the prominent role played by antibodies among which IgE, and also the activation of the cytotoxic activity by mast cell-derived ECF. A tetrapeptides. The demonstration of the cytolytic effect of basic proteins present in eosinophil granules allows to clarify this mechanism on a molecular basis. Eosinophil effector function is then envisaged in various clinical situations. In pulmonary eosinophilias, a relation appears between the detection of proteins released by eosinophils and the tissue damage. Eosinophils seem also to be implied in the inflammatory process characteristic of endomyocardial disease or in Crohn's disease. Whereas they were first considered as beneficial cells for the host, the eosinophil granulocytes may therefore express according to the targets, a dual either beneficial or nocious function.
在实验模型中研究了嗜酸性粒细胞的效应功能，重点强调了抗体（尤其是IgE）所起的重要作用，以及肥大细胞衍生的嗜酸性粒细胞趋化因子对细胞毒性活性的激活作用。一种四肽。嗜酸性粒细胞颗粒中存在的碱性蛋白的细胞溶解作用的证明有助于从分子层面阐明这一机制。然后在各种临床情况下设想嗜酸性粒细胞的效应功能。在肺部嗜酸性粒细胞增多症中，嗜酸性粒细胞释放的蛋白质检测与组织损伤之间似乎存在关联。嗜酸性粒细胞似乎也参与了心内膜疾病或克罗恩病的特征性炎症过程。鉴于它们最初被认为是对宿主有益的细胞，因此嗜酸性粒细胞可能根据靶标表现出有益或有害的双重功能。
