Bernengo M G, Lisa F, Puiatti P, Meregalli M, Berruto G, Zina G
Thymus. 1983 Apr;5(3-4):223-33.
Functional T-cell subpopulations have been evaluated in the peripheral blood of 124 melanoma patients (71 non-metastatic and 53 metastatic) using monoclonal antibodies: OKT3, OKT4, OKT8, every 2 months for 1 year. The levels of OKT3+ cells were significantly lower in metastatic patients than in normal controls and they decreased in the advanced phases of the disease. Percentages and absolute OKT4+ cell values were reduced in metastatic patients only, while a significant reduction in OKT8+ cells was noted in both long-surviving, non-metastatic and metastatic patients. The ratio of OKT4+/OKT8+ cells was increased in non-metastatic patients and in patients remaining metastasis-free for 4 years after resection of their metastases. Patients with prolonged survival show normal T-helper cells and low T-suppressor cells with a significant increased ratio OKT4/OKT8. In the patients who developed visceral metastases and in those who died the progressive reduction in total T cells is mainly due to the decrease in OKT4+ cells.
使用单克隆抗体OKT3、OKT4、OKT8，对124例黑色素瘤患者（71例非转移性和53例转移性）的外周血中的功能性T细胞亚群进行了为期1年、每2个月一次的评估。转移性患者中OKT3 +细胞水平显著低于正常对照组，且在疾病晚期有所下降。仅转移性患者的OKT4 +细胞百分比和绝对值降低，而在长期存活的非转移性和转移性患者中均观察到OKT8 +细胞显著减少。非转移性患者以及转移灶切除后4年无转移的患者中，OKT4 + /OKT8 +细胞比值升高。长期存活的患者表现为正常的辅助性T细胞和低水平的抑制性T细胞，OKT4/OKT8比值显著增加。发生内脏转移的患者以及死亡患者中，总T细胞的逐渐减少主要是由于OKT4 +细胞的减少。
