Hashimoto K, Iwahara K
Am J Dermatopathol. 1983 Apr;5(2):129-34. doi: 10.1097/00000372-198304000-00010.
For the purpose of diagnosing and staging cutaneous T-cell lymphoma, the nuclear contour index and subsets of T-cells in the lesions were studied. Nuclear contour index measured in T-cells identified precisely with monoclonal pan-T antibody was found to be higher than nuclear contour index measured in T-cell-like cells with significant nuclear convolution. Nuclear contour index increased as the disease progressed from erythematous to tumor stage or to the Sézary syndrome. The relative ratio of suppressor cytotoxic T-cells to helper T-cells was higher in the early rather than late stage of cutaneous T-cell lymphoma.
为了对皮肤T细胞淋巴瘤进行诊断和分期，对病变中T细胞的核轮廓指数和T细胞亚群进行了研究。发现用单克隆泛T抗体精确识别的T细胞中测得的核轮廓指数高于具有明显核卷曲的T细胞样细胞中测得的核轮廓指数。随着疾病从红斑期发展到肿瘤期或Sezary综合征，核轮廓指数升高。皮肤T细胞淋巴瘤早期抑制性细胞毒性T细胞与辅助性T细胞的相对比例高于晚期。
