Kikuchi K, Kusama S, Furue H, Muto T, Toriyama K, Wakiya M
Gan To Kagaku Ryoho. 1983 Aug;10(8):1866-71.
This study was designed to evaluate the most effective administration method of NCS for advanced carcinoma of the stomach, mainly nonresectable and/or recurrent cases which were collected by our cooperative study group. Nine hundred seventy six cases were available for clinical evaluation. Rate of the efficacy of NCS alone and combined with 5-FU was higher (P less than 0.1) in the cases administrated intravenously by drip infusion than in those by one shot injection method, and adverse effects were fewer in the former than in the latter cases. The rate of efficacy of NCS was higher in cases treated with 4,000 mu/day alone intermittently 2-3 times for a week than in those with 2,000 mu/day alone every day. The rate of clinical effect was higher in the cases treated with 4,000 mu of NCS combined with 50 mg of 5-FU intermittently than in those with 2,000 mu of NCS combined with 250 mg of 5-FU every day, especially 20.6% of the former cases given more than 50,000 mu of NCS were interpreted as clinically effective by Karnofsky's criteria of I-A over.
本研究旨在评估丝裂霉素（NCS）对晚期胃癌（主要是不可切除和/或复发病例，由我们的合作研究组收集）的最有效给药方法。976例患者可用于临床评估。丝裂霉素单独使用及与5-氟尿嘧啶（5-FU）联合使用时，静脉滴注给药患者的有效率高于（P<0.1）一次性注射给药患者，且前者的不良反应少于后者。丝裂霉素单独使用时，每周间歇2-3次、每次4000单位/天的患者有效率高于每天2000单位/天的患者。丝裂霉素4000单位与5-氟尿嘧啶50毫克联合间歇给药患者的临床有效率高于丝裂霉素2000单位与5-氟尿嘧啶250毫克每日联合给药患者，尤其是根据卡诺夫斯基（Karnofsky）I-A及以上标准，前者接受超过50000单位丝裂霉素治疗的患者中20.6%被判定为临床有效。
