Péjaudier L, Kichenin V, Audran R, Steinbuch M
Hoppe Seylers Z Physiol Chem. 1983 Jun;364(6):651-4. doi: 10.1515/bchm2.1983.364.1.651.
Plasma kallikrein activation occurs frequently during blood drawing and subsequent plasma handling. The purified enzyme was incubated with ceruloplasmin, inter-alpha-trypsin inhibitor and complement factor C4. Proteolysis caused by this enzyme was compared with the degradative effects of plasmin and thrombin. Among these proteins C4 proved to be most easily degraded; its cleavage products can interact with C4-binding protein.
血浆激肽释放酶的激活在采血及随后的血浆处理过程中经常发生。将纯化的该酶与铜蓝蛋白、α-胰蛋白酶抑制剂及补体因子C4一起孵育。将这种酶引起的蛋白水解作用与纤溶酶和凝血酶的降解作用进行比较。在这些蛋白质中，C4被证明最易降解；其裂解产物可与C4结合蛋白相互作用。
