Responses of cat peroneus brevis muscle spindle afferents during recovery from nerve-crush injury.

The responses of regenerated muscle spindle afferents to ramp-and-hold stretch of the peroneus brevis muscle in the cat were recorded at periods from 26 to 140 days after crushing the common peroneal nerve. During the early stages of recovery a number of abnormally responding afferents were observed. The most marked abnormality was the absence or rapid failure of firing during the held phase of the stretch. The proportion of abnormal afferents became less as recovery progressed. Electrical stimulation of isolated static and dynamic gamma-axons increased the firing rates of the afferents during the ramp-and-hold stretch such that a gamma static axon would restore the response of an abnormal afferent to the held phase of the stretch. The regenerated afferents have been classified according to the degree of abnormality displayed. These abnormalities can be accounted for by assuming a subtractive reduction in the firing frequency of the regenerated afferents. This is attributed to an increase in the pacemaker threshold.