Koó E, Fehér K G, Fehér T, Füst G
Klin Wochenschr. 1983 Jul 15;61(14):715-7. doi: 10.1007/BF01487618.
Hereditary angioneurotic edema (HAE) is a complement-related clinical disorder with a deficiency of the C1 esterase inhibitor protein. Eight patients with severe attacks of the disease were treated with the adrenal "androgen" dehydroepiandrosterone sulphate (DS). Steroid therapy for 3-28 months resulted in dramatic improvement in their clinical state and a moderate increase in the serum concentration of C1 inhibitor. There was a significant increase in the serum level of either unconjugated dehydroepiandrosterone (D) or of DS during treatment.
遗传性血管性水肿（HAE）是一种与补体相关的临床疾病，伴有C1酯酶抑制蛋白缺乏。8例患有该疾病严重发作的患者接受了肾上腺“雄激素”硫酸脱氢表雄酮（DS）治疗。3至28个月的类固醇治疗使他们的临床状态得到显著改善，C1抑制剂的血清浓度适度增加。治疗期间，未结合的脱氢表雄酮（D）或DS的血清水平显著升高。
