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[小鼠T细胞的辐射损伤与恢复。辐射作用后抑制细胞的动态变化]

[Radiation damage to and recovery of mouse T-cells. Dynamics of suppressor cells after the effects of radiation].

作者信息

Iarilin A A, Polushkina E F

出版信息

Radiobiologiia. 1983 Jul-Aug;23(4):454-7.

PMID:6225142
Abstract

Suppressor and helper T-cells precursors, similar in radiosensitivity (D0 = 2.16 and 2.25, respectively), are restored almost synchronously reaching a normal level by the end of the 2nd month after irradiation. Suppressor macrophage precursors remain intact at doses of up to 7 Gy: one month after irradiation their level decreases perhaps because of the death of the radiosensitive precursors. The suppressors damage is one of the factors decelerating the reverse development of the immune response after irradiation.

摘要

抑制性T细胞和辅助性T细胞前体的放射敏感性相似(D0分别为2.16和2.25),在照射后第2个月末几乎同步恢复到正常水平。抑制性巨噬细胞前体在剂量高达7 Gy时保持完整:照射后1个月其水平下降,可能是由于放射敏感前体的死亡。抑制因子的损伤是照射后免疫反应逆向发展减速的因素之一。

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