Didier R
C R Seances Soc Biol Fil. 1983;177(3):304-12.
The effects of 2,4,5-T on the hepatic cell in the 13 day old quail embryo have been studied. When injected at the dose level of 80 or 240 mg/kg into non-incubated eggs, this herbicide induces a proliferation of the smooth endoplasmic reticulum. The ergastoplasmic cisternae are dilated and feature a decrease in ribosomic covering. The mitochondria are swollen showing a pale matrix and a deficiency in cristae. One also observes an increase in the amount and size of lipidic inclusions and a dilatation of bile canaliculi. Moreover, biochemical analysis reveals a significant decrease in the glycogen content indicating that 2,4,5-T disturbs the glycogenic function of the liver.
已对2,4,5-涕对13日龄鹌鹑胚胎肝细胞的影响进行了研究。当以80或240毫克/千克的剂量水平注入未孵化的卵中时，这种除草剂会诱导滑面内质网增殖。内质网池扩张，核糖体覆盖减少。线粒体肿胀，基质变淡，嵴缺乏。还观察到脂质包涵体的数量和大小增加以及胆小管扩张。此外，生化分析显示糖原含量显著降低，表明2,4,5-涕扰乱了肝脏的糖原合成功能。
