Montes L F, Cordero A A, Kriner J, Loder J, Flanagan A D
Cutis. 1983 Aug;32(2):185-90.
A group of patients with acne rosacea was treated with 5 percent benzoyl peroxide acetone gel for four weeks and then with 10 percent benzoyl peroxide acetone gel for an additional four weeks. A parallel group of patients was treated with a matching placebo (acetone gel vehicle). At the end of the first four weeks of treatment the dropout rate due to lack of improvement was 23 and 63 percent for benzoyl peroxide acetone gel and placebo, respectively. Benzoyl peroxide acetone gel was superior to placebo with respect to improvement in the overall severity of the lesions when judged by photographs, and by reduction of erythema, papules, and pustules. Results after treatment with benzoyl peroxide acetone gel were better during weeks five to eight than during weeks one to four for all lesions except telangiectasia. Benzoyl peroxide acetone gel was superior to placebo when the overall responses were compared. In addition, the benzoyl peroxide acetone gel-treated group, but not the placebo-treated group, showed a significantly better response during weeks five to eight compared to weeks one to four.
一组酒渣鼻患者先用5%过氧化苯甲酰丙酮凝胶治疗四周，然后再用10%过氧化苯甲酰丙酮凝胶额外治疗四周。另一组平行患者接受匹配的安慰剂（丙酮凝胶基质）治疗。在治疗的前四周结束时，由于病情无改善导致的脱落率在过氧化苯甲酰丙酮凝胶组和安慰剂组分别为23%和63%。通过照片判断病变的总体严重程度改善情况，以及通过红斑、丘疹和脓疱的减少情况来判断，过氧化苯甲酰丙酮凝胶优于安慰剂。除了毛细血管扩张外，对于所有病变，过氧化苯甲酰丙酮凝胶在五至八周的治疗效果都优于一至四周。当比较总体反应时，过氧化苯甲酰丙酮凝胶优于安慰剂。此外，与一至四周相比，过氧化苯甲酰丙酮凝胶治疗组在五至八周时显示出明显更好的反应，但安慰剂治疗组没有。
