Okawa H, Doi K
Jikken Dobutsu. 1983 Apr;32(2):77-84. doi: 10.1538/expanim1978.32.2_77.
Pathological examination was carried out on 16 male Sprague-Dawley rats received single i. v. injection of 60 mg/kg of streptozotocin (SZ) at 5 weeks of age and maintained for 22 months. Insulinoma (63%), renal adenoma (50%), hepatocellular tumor (69%), cholangioma (31%) and Leydig cell tumor (56%) were found in a high incidence, and therefore occurrence of these tumors was considered to be attributable to the treatment with SZ. In addition to these tumors, though in a low incidence, various such tumors as leukemia, reticulum cell sarcoma, mammary tumor and glioma were also found.
对16只5周龄雄性斯普拉格-道利大鼠进行了病理检查，这些大鼠接受了单次静脉注射60mg/kg链脲佐菌素（SZ），并维持22个月。发现胰岛素瘤（63%）、肾腺瘤（50%）、肝细胞瘤（69%）、胆管瘤（31%）和睾丸间质细胞瘤（56%）的发生率很高，因此认为这些肿瘤的发生归因于SZ治疗。除了这些肿瘤外，虽然发生率较低，但也发现了各种肿瘤，如白血病、网状细胞肉瘤、乳腺肿瘤和胶质瘤。
