Davis W J, Gillette R
Science. 1978 Feb 17;199(4330):801-4. doi: 10.1126/science.622572.
Food stimuli normally excite the command neurons of Pleurobranchaea that cause feeding. In contrast, the same food stimuli selectively inhibit these neurons in specimens that have been trained to suppress feeding and withdraw from food by means of an avoidance conditioning paradigm consisting of paired food and conditional shock. Food stimuli excite the feeding command neurons of yoked control specimens exposed to unpaired food and shock, but inhibit the feeding command neurons of untrained specimens that have been satiated with food. These results suggest that the command neurons serve as a neural locus at which an animal's behavior is modulated by past experiences. These results also establish a neural correlate of behavioral plasticity, in the form of synaptic inhibition of the command neurons.
食物刺激通常会激发侧鳃海蛞蝓中引发进食的指令神经元。相比之下，在通过由配对食物和条件性电击组成的回避条件范式训练以抑制进食并远离食物的标本中，相同的食物刺激会选择性地抑制这些神经元。食物刺激会激发接受未配对食物和电击的被束缚对照标本的进食指令神经元，但会抑制已饱食的未训练标本的进食指令神经元。这些结果表明，指令神经元作为一个神经位点，动物的行为在此受到过去经历的调节。这些结果还以指令神经元的突触抑制形式建立了行为可塑性的神经关联。
