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巯基与甲状腺素单碘脱碘生成三碘甲状腺原氨酸

Sulfhydryl groups and the monodeiodination of thyroxine to triiodothyronine.

作者信息

Chopra I J

出版信息

Science. 1978 Feb 24;199(4331):904-6. doi: 10.1126/science.622575.

DOI:10.1126/science.622575
PMID:622575
Abstract

Sulfhydryl reagents exert a profound influence on the monodeiodination of thyroxine to triiodothyronine by rat and sheep tissues in vitro. A marked dithiothreitol-induced increase in the monodeiodination by fetal sheep liver homogenates suggests that the characteristically low conversion in fetal tissues is related more to the status of sulfhydryl groups than to a deficiency of the monodeiodinating enzyme.

摘要

巯基试剂对大鼠和绵羊组织在体外将甲状腺素单碘化转化为三碘甲状腺原氨酸的过程有着深远影响。二硫苏糖醇显著诱导胎羊肝匀浆的单碘化作用增强，这表明胎儿组织中典型的低转化率更多地与巯基状态有关，而非与单碘化酶的缺乏有关。

相似文献

1
Sulfhydryl groups and the monodeiodination of thyroxine to triiodothyronine.巯基与甲状腺素单碘脱碘生成三碘甲状腺原氨酸
Science. 1978 Feb 24;199(4331):904-6. doi: 10.1126/science.622575.
2
The role of sulfhydryl groups on the impaired hepatic 3',3,5-triiodothyronine generation from thyroxine in the hypothyroid, starved, fetal, and neonatal rodent.巯基在甲状腺功能减退、饥饿、胎儿及新生啮齿动物肝脏中甲状腺素生成受损的3',3,5-三碘甲状腺原氨酸过程中的作用
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The mechanism of low serum T3 in the fetus: hepatic T4-5'-monodeiodinase versus tissue sulfhydryl content--a clarification.
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[A study of the conversion of thyroxine to 3, 3', 5-triiodothyronine in the rat liver: the mechanism of stimulatory effects of thiols on T4 5'-deiodinase (author's transl)].大鼠肝脏中甲状腺素向3,3',5-三碘甲状腺原氨酸的转化研究：硫醇对T4 5'-脱碘酶刺激作用的机制（作者译）
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Effect of sulfhydryl reagents on the conversion of thyroxine to 3,5,3'-triiodothyronine: direct action on thyroxine molecules.
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Alterations in monodeiodination of iodothyronines in the fasting rat: effects of reduced nonprotein sulfhydryl groups and hypothyroidism.禁食大鼠甲状腺原氨酸单碘脱碘作用的改变：非蛋白巯基减少和甲状腺功能减退的影响。
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Preincubation of thyroxine with sulfhydryl-reducing agents does not stimulate thyroxine inner or outer ring deiodination.
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Decreased outer ring monodeiodination of thyroxine and reverse triiodothyronine in the fetal and neonatal rat.
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Evaluation of thyroxine monodeiodination to reverse triiodothyronine by tissue homogenates in vitro.体外通过组织匀浆评估甲状腺素单碘化生成反三碘甲状腺原氨酸的过程。
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Monodeiodination of thyroxine in the maternal and fetal dog kidneys and placenta.
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引用本文的文献

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In vitro hepatic monodeiodination of L-thyroxine and the temporal effect of 17β-estradiol on deiodination in rainbow trout (Salmo gairdneri Richardson).体外肝中单碘甲状腺原氨酸和 17β-雌二醇对虹鳟（Salmo gairdneri Richardson）脱碘作用的时间效应。
Fish Physiol Biochem. 1989 May;6(3):129-38. doi: 10.1007/BF01874769.
2
Expression of a soluble form of iodotyrosine deiodinase for active site characterization by engineering the native membrane protein from Mus musculus.通过对来自 Mus musculus 的天然膜蛋白进行工程改造，表达一种可溶性形式的碘酪氨酸脱碘酶，用于活性位点表征。
Protein Sci. 2012 Mar;21(3):351-61. doi: 10.1002/pro.2020.
3
Inhibition of rat hepatic thyroxine 5'-monodeiodinase by propylthiouracil: relation to site of interaction of thyroxine and glutathione.
丙硫氧嘧啶对大鼠肝脏甲状腺素5'-单脱碘酶的抑制作用：与甲状腺素和谷胱甘肽相互作用位点的关系。
J Endocrinol Invest. 1981 Oct-Dec;4(4):379-87. doi: 10.1007/BF03348299.
4
The effect of bile salts on thyroxine 5'-monodeiodination in rat liver homogenate.
Experientia. 1981 Jun;37(6):601-2. doi: 10.1007/BF01990073.
5
Thyroid hormone metabolism in primary cultured rat hepatocytes. Effects of glucose, glucagon, and insulin.原代培养大鼠肝细胞中的甲状腺激素代谢。葡萄糖、胰高血糖素和胰岛素的作用。
J Clin Invest. 1981 Aug;68(2):475-83. doi: 10.1172/jci110278.
6
Relationships between iodothyronine peripheral metabolism and ketone bodies during hypocaloric dietary manipulations.低热量饮食干预期间甲状腺原氨酸外周代谢与酮体之间的关系。
J Endocrinol Invest. 1983 Apr;6(2):81-9. doi: 10.1007/BF03350577.
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Structural requirements of thiol compounds in the inhibition of human liver iodothyronine 5'-deiodinase.硫醇化合物对人肝脏碘甲状腺原氨酸5'-脱碘酶抑制作用的结构要求
Biochem J. 1984 Jan 15;217(2):485-91. doi: 10.1042/bj2170485.
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Formation of diiodotyrosine from thyroxine. Ether-link cleavage, an alternate pathway of thyroxine metabolism.由甲状腺素形成二碘酪氨酸。醚键断裂，甲状腺素代谢的另一条途径。
J Clin Invest. 1983 Oct;72(4):1234-45. doi: 10.1172/JCI111079.
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Ontogenesis of iodothyronine-5'-deiodinase. Induction of 5'-deiodinating activity by insulin, glucocorticoid, and thyroxine in cultured fetal mouse liver.碘甲状腺原氨酸5'-脱碘酶的个体发生。胰岛素、糖皮质激素和甲状腺素对培养的胎鼠肝脏5'-脱碘活性的诱导作用。
J Clin Invest. 1984 Dec;74(6):2254-62. doi: 10.1172/JCI111652.
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Biochem J. 1986 Mar 1;234(2):391-8. doi: 10.1042/bj2340391.