Rifkin S I, de Quesada A M, Pickering M J, Shires D L
South Med J. 1978 Jan;71(1):86-8. doi: 10.1097/00007611-197801000-00029.
A patient with Hodgkin's disease and renal insufficiency became deaf while being treated with high dose oral furosemide. Cessation of furosemide was associated with improvement in his hearing. However, at the time of his death, 11 days after stopping the furosemide, significant hearing impairment was still present. It is suggested that oral furosemide be considered potentially ototoxic, particularly in patients with compromised renal function.
一名患有霍奇金病和肾功能不全的患者在接受大剂量口服速尿治疗时出现了耳聋。停用速尿后其听力有所改善。然而，在停止使用速尿11天后患者死亡时，仍存在明显的听力障碍。提示口服速尿可能具有潜在耳毒性，尤其是对肾功能受损的患者。
