[Modification of an enzymic system of Ca2+ transport in sarcoplasmic reticulum membranes during lipid peroxidation. Induction and regulation systems of lipid peroxidation in skeletal and heart muscles].

The enzymic and non-enzymic systems which induce and control lipid peroxidation (LPO) in muscle cells were studied. The maximal activity of enzymic NADH- and NADPH-dependent LPO was observed in sarcoplasmic reticulum (SR) membranes. It was found that an essential role in enzymic LPO induction belongs to superoxide radical anions and to hydroxyl radicals. The maximal concentration of the natural LPO inhibitor, alpha-tocopherol, was detected in SR membranes. The glutathione peroxidase and superoxide dismutase activities were determined in the cytosol fraction of myocytes. The role of compartmentation of enzymic and non-enzymic systems of LPO induction in muscle cells is discussed.