El-Domeiri A A, Das Gupta T K, Trippon M, Simo C, Sabet T Y, Crispen R
Surg Gynecol Obstet. 1978 Feb;146(2):230-2.
Thirty-one patients with Stage II cutaneous melanoma received adjuvant chemotherapy or immunotherapy after radical excision of the primary and regional lymph nodes. Vaccinations with bacille Calmette Guérin produced minimal systemic reactions and was better tolerated by the patients than was chemotherapy. A higher survival rate and disease-free interval were noted in patients treated with bacille Calmette Guérin than those receving dimethyl Triazeno-imidazole carboximide. These results suggest that adjuvant chemotherapy with dimethyl Triazenoimidazole carboximide alone is not beneficial in the treatment of high risk patients with melanoma. In this study, adjuvant bacille Calmette Guérin therapy appears to be more advantageous than does chemotherapy.
31例II期皮肤黑色素瘤患者在原发灶和区域淋巴结根治性切除后接受了辅助化疗或免疫治疗。卡介苗接种产生的全身反应极小，患者对其耐受性优于化疗。接受卡介苗治疗的患者比接受二甲基三氮烯咪唑甲酰胺治疗的患者生存率更高，无病生存期更长。这些结果表明，单独使用二甲基三氮烯咪唑甲酰胺进行辅助化疗对高危黑色素瘤患者的治疗并无益处。在本研究中，辅助卡介苗治疗似乎比化疗更具优势。
