[Amineptine versus imipramine. Double-blind controlled study].

The antidepressant properties of amineptine and imipramine were compared in a double-blind controlled trial involving 38 patients randomized to one or the other treatment. The results were evaluated globally using three scales of psychiatric assessment: Hamilton's depression rating scale, brief psychiatric rating scale (Pichot, Overall and Gorham) and nursing staff observation scale (N.O.S.I.E.). Statistical analysis of the overall score, individual items and grouped items failed to demonstrate any significant difference between the two drugs for the periods considered. Detailed information is provided on the acceptability of both drugs, particularly as regards the cardiovascular system.