Legrand Y J, Karniguian A, Fauvel F
Presse Med. 1983 Oct 22;12(37):2327-30.
Biochemical methods involving chemical and enzymatic cleavage of type III collagen (characteristic of arterial subendothelium) have led to the identification of a nonapeptide common to different overlapping collagen fragments capable of interacting with platelets. This nonapeptide has been synthesized; it specifically inhibits platelet aggregation and secretion of endogenous platelet serotonin by type III collagen from which it originates. Its effect on platelet adhesion is moderate. In view of its specificity in the platelet-collagen interaction, its use as a mean of preventing thrombosis can be envisaged.
涉及对III型胶原蛋白（动脉内皮下层的特征性成分）进行化学和酶切的生化方法，已鉴定出一种存在于不同重叠胶原蛋白片段中的九肽，该九肽能够与血小板相互作用。这种九肽已被合成；它能特异性抑制其来源的III型胶原蛋白诱导的血小板聚集和内源性血小板5-羟色胺的分泌。它对血小板黏附的作用适中。鉴于其在血小板-胶原蛋白相互作用中的特异性，可以设想将其用作预防血栓形成的手段。
