Belousov Iu B, Panchenko E P, Kudaev M T, Ermolin G A, Rudakov A V
Kardiologiia. 1983 Oct;23(10):41-6.
A total of 250 subjects were investigated using a diagnostic search flow-chart. Pulmonary artery thromboembolism (PATE) was diagnosed in 102 patients. The results have demonstrated the value of laboratory tests employed--markers of thrombin- and plasminemia and platelet activation--for PATE diagnosis. To diagnose PATE, levels of fibrinogen-fibrin and beta-thromboglobulin degradation products should be measured in myocardial infarction patients, and plasma soluble fibrin measurement should be added to those in patients with circulatory insufficiency. In recurrent PATE, continuous increase of plasma beta-thromboglobulin and soluble fibrin levels, antithrombin III exhaustion and reduced levels of fibrinogen-fibrin degradation products are of diagnostic value.
使用诊断搜索流程图对总共250名受试者进行了调查。102例患者被诊断为肺动脉血栓栓塞症(PATE)。结果证明了所采用的实验室检测——凝血酶和纤溶酶血症标志物以及血小板活化标志物——对PATE诊断的价值。为诊断PATE,应在心肌梗死患者中检测纤维蛋白原 - 纤维蛋白和β-血小板球蛋白降解产物的水平,对于循环功能不全患者还应增加血浆可溶性纤维蛋白检测。在复发性PATE中,血浆β-血小板球蛋白和可溶性纤维蛋白水平持续升高、抗凝血酶III耗竭以及纤维蛋白原 - 纤维蛋白降解产物水平降低具有诊断价值。