通过D1刺激在未接触过相关药物的大鼠中诱发口腔运动障碍。
Induction of oral dyskinesias in naive rats by D1 stimulation.
作者信息
Rosengarten H, Schweitzer J W, Friedhoff A J
出版信息
Life Sci. 1983 Dec 19;33(25):2479-82. doi: 10.1016/0024-3205(83)90155-8.
PMID:6227782
Abstract
Repetitious opening and closing of the mouth and high frequency clonic jaw movements were observed in rats challenged with dopamine agonists after acute treatment with sulpiride or a low dose of spiroperidol. SKF 38393, a specific D1 receptor agonist, alone, also induced these behaviors and cis-flupenthixol blocked them, evidence suggesting D1 dopamine receptor mediation.
摘要
在用舒必利或低剂量螺哌啶醇急性处理后，给予多巴胺激动剂的大鼠出现了反复的张嘴和闭嘴动作以及高频阵挛性下颌运动。特异性D1受体激动剂SKF 38393单独使用也可诱发这些行为，而顺式氟哌噻吨可阻断这些行为，这一证据表明是D1多巴胺受体介导的。
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