Loew D M
Presse Med. 1983 Dec 29;12(48):3141-6.
In order to promote optimal characterization of new drugs for the psychogeriatric patient, a clear delineation of both patients and therapies is needed. Diagnostic evaluation of the patient includes a careful differential diagnosis, a definition of target symptoms and an evaluation of severity and stage of disease. Criteria for assessment of drug efficacy must take into account the pharmacological effects of the drug, the hypothesis to be investigated and the target population. Drug assessment should include indicators of drug activity such as physiological, biochemical or psychometric measurements. In order to facilitate progress in geriatric psychopharmacology, full use should be made of the various hypothesis for drug treatment originating from the rapid advancement in our understanding of the biological basis of senile mental incapacitation.
为了促进对老年精神病患者新药的最佳特性描述，需要对患者和治疗方法进行清晰的界定。对患者的诊断评估包括仔细的鉴别诊断、目标症状的定义以及疾病严重程度和阶段的评估。药物疗效评估标准必须考虑药物的药理作用、待研究的假设以及目标人群。药物评估应包括药物活性指标，如生理、生化或心理测量指标。为了促进老年精神药理学的进展，应充分利用源于我们对老年精神功能衰退生物学基础认识的快速进步而产生的各种药物治疗假设。
