Basile V, Amoroso S, Di Renzo G F
Boll Soc Ital Biol Sper. 1983 Oct 30;59(10):1442-6.
These experiments were performed in order to further clarify the role played by hystamine in the control of hypothalamus-hypophisis-adrenal axis. To this aim we evaluated the effect of Dimaprit, a H2 agonist on plasma corticosterone levels. This drug was administered intraperitoneally or i.c.v. at the doses of 25, 50 and 100 mg/kg or 100 gamma/animal respectively. The administration i.p. at the dose of 100 mg/kg increased plasma-corticosterone levels whereas Dimaprit, injected intraventricularly did not modify plasma-corticosterone levels. These results seem to suggest that Dimaprit stimulates corticosterone secretion at a peripheral level.
进行这些实验是为了进一步阐明组胺在下丘脑-垂体-肾上腺轴调控中所起的作用。为此，我们评估了H2激动剂二甲双胍对血浆皮质酮水平的影响。该药物分别以25、50和100 mg/kg或100微克/动物的剂量腹腔注射或脑室内注射。腹腔注射100 mg/kg剂量可提高血浆皮质酮水平，而脑室内注射二甲双胍则不会改变血浆皮质酮水平。这些结果似乎表明，二甲双胍在周围水平刺激皮质酮分泌。
