Anton R F, Sexauer J D, Randall C L
J Affect Disord. 1983 Nov;5(4):305-10. doi: 10.1016/0165-0327(83)90020-4.
It has been suggested that the antidepressant amoxapine might have neuroleptic properties. Clinically, an increase in serum prolactin occurs during neuroleptic treatment secondary to post-synaptic dopamine blockade. Ten men who met DSM-III criteria for major depression exhibited a significant increase in their serum prolactin over drug-free baseline values during treatment with amoxapine. A comparison group of 12 depressed men treated with desipramine showed no such increase. Combined with that of others, our study suggests that amoxapine might have antipsychotic properties and, therefore, be useful in treating conditions where a combined antidepressant and neuroleptic effect is required.
有人提出抗抑郁药阿莫沙平可能具有抗精神病特性。临床上，在抗精神病药物治疗期间，由于突触后多巴胺阻断，血清催乳素会升高。10名符合DSM-III重度抑郁症标准的男性在接受阿莫沙平治疗期间，其血清催乳素水平较无药物治疗的基线值有显著升高。另一组12名接受去甲丙咪嗪治疗的抑郁症男性则未出现这种升高。结合其他研究结果，我们的研究表明阿莫沙平可能具有抗精神病特性，因此，在需要联合抗抑郁和抗精神病作用的情况下可能有用。
