Yamawaki S, Lai H, Horita A
Life Sci. 1984 Jan 30;34(5):467-74. doi: 10.1016/0024-3205(84)90502-2.
The effects of dopaminergic and serotonergic drugs on ethanol-induced hypothermia were studied in the rat. Pretreatment with haloperidol attenuated the hypothermia in a dose-dependent manner. Apomorphine produced a dose-dependent effect on the hypothermia. At a dose of 2.0 mg/kg, apomorphine potentiated ethanol-induced hypothermia, whereas at 0.1 mg/kg, it produced a delayed attenuation effect between 30 min and 45 min after its injection. The former effect was blocked by haloperidol, whereas the latter was not affected by haloperidol, but blocked by pretreatment with parachlorophenylalanine. It is concluded that both dopamine and serotonin exert modulatory effects on ethanol-induced hypothermia.
研究了多巴胺能和血清素能药物对大鼠乙醇诱导的体温过低的影响。用氟哌啶醇预处理以剂量依赖的方式减轻了体温过低。阿扑吗啡对体温过低产生剂量依赖性效应。在2.0毫克/千克的剂量下，阿扑吗啡增强了乙醇诱导的体温过低，而在0.1毫克/千克时，它在注射后30分钟至45分钟之间产生延迟的减轻效应。前一种效应被氟哌啶醇阻断，而后一种效应不受氟哌啶醇影响，但被对氯苯丙氨酸预处理阻断。结论是多巴胺和血清素均对乙醇诱导的体温过低发挥调节作用。
