Ozaki S, Watanabe Y, Hoshiko T, Ii S, Kagawa T
Nucleic Acids Symp Ser. 1983(12):9-12.
3',5'-Diacyl-2'-bromo-5-fluoro-2'-deoxyuridine (4) was obtained by the reaction of 5, 6-dihydro-6-hydroxy-5-fluorouridine (2) and acyl bromide. Because the route from uridine (1) to 2, the route from 4 to 3',5'-diacyl-5-fluoro-2'-deoxyuridine (5), and the route from 5 to 5-fluoro-2'-deoxyuridine (FUDR, 6) are known reactions, the three step synthesis from uridine to 5 and four step synthesis from uridine to FUDR have been accomplished.
3',5'-二酰基-2'-溴-5-氟-2'-脱氧尿苷（4）是通过5,6-二氢-6-羟基-5-氟尿苷（2）与酰溴反应制得的。由于从尿苷（1）到2的路线、从4到3',5'-二酰基-5-氟-2'-脱氧尿苷（5）的路线以及从5到5-氟-2'-脱氧尿苷（氟尿苷，6）的路线都是已知反应，因此已经完成了从尿苷到5的三步合成以及从尿苷到氟尿苷的四步合成。
