Fletcher-McGruder B L, Gerritsen G C
Proc Soc Exp Biol Med. 1984 Jan;175(1):74-8. doi: 10.3181/00379727-175-41769.
The antibody responses of spontaneously diabetic Chinese hamsters to sheep erythrocytes was investigated. After primary challenge, total antibody production of the diabetics was only 50% or less than that of nondiabetic controls, and little or no switchover to IgG production occurred. After second challenge, total antibody of diabetics was still reduced compared with controls. Some switchover to IgG did occur after second challenge but was only 40% that of controls. Poor antibody response was not related to abnormal glucose metabolism since low titers and lack of IgG was found in euglycemic prediabetics. Additionally, genetic nondiabetics rendered hyperglycemic by streptozotocin responded normally, similar to euglycemic controls. The impaired humoral antibody response of the diabetic hamster is similar to that reported for some human diabetics and makes this animal model attractive for studying the consequences and possible causes of diabetes-dependent impairment of immune responses.
对自发性糖尿病中国仓鼠针对绵羊红细胞的抗体反应进行了研究。初次激发后，糖尿病仓鼠的总抗体产生量仅为非糖尿病对照组的50%或更低，且很少或几乎没有向IgG产生的转换。再次激发后，糖尿病仓鼠的总抗体量与对照组相比仍有所降低。再次激发后确实发生了向IgG的一些转换，但仅为对照组的40%。抗体反应不佳与葡萄糖代谢异常无关，因为在血糖正常的糖尿病前期患者中发现了低滴度且缺乏IgG。此外，通过链脲佐菌素诱导高血糖的遗传性非糖尿病仓鼠反应正常，类似于血糖正常的对照组。糖尿病仓鼠体液抗体反应受损与一些人类糖尿病患者的情况相似，这使得该动物模型对于研究糖尿病相关免疫反应受损的后果及可能原因具有吸引力。
