给予5-羟色胺摄取抑制剂齐美利定的阿片类成瘾大鼠吗啡摄入量减少。
Decreased morphine intake by opiate addicted rats administered zimelidine, a 5-HT uptake inhibitor.
作者信息
Rönnbäck L, Zeuchner J, Rosengren L, Wronski A, Ogren S O
出版信息
Psychopharmacology (Berl). 1984;82(1-2):30-5. doi: 10.1007/BF00426376.
Zimelidine, a specific 5-HT uptake inhibitor, reduced peroral morphine consumption by morphine-addicted adult male and female Sprague-Dawley rats and old male rats in choice tests. The effect was dose dependent in male rats. Thus, the availability of central 5-HT appears to be important for the regulation of morphine preference in rat. The results are discussed in relation to recent literature where ethanol preference has been found to be attenuated by zimelidine. The results may provide insights into the complex cellular mechanisms underlying opiate addiction.
齐美利定是一种特异性5-羟色胺摄取抑制剂，在选择试验中，它能减少吗啡成瘾的成年雄性和雌性斯普拉格-道利大鼠以及老年雄性大鼠的口服吗啡摄入量。在雄性大鼠中，这种作用呈剂量依赖性。因此，中枢5-羟色胺的可利用性似乎对大鼠吗啡偏好的调节很重要。结合最近发现齐美利定可减弱乙醇偏好的文献对这些结果进行了讨论。这些结果可能为阿片类药物成瘾背后复杂的细胞机制提供见解。
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