Leung C M, Ogle C W, Dai S
Pharmacol Biochem Behav. 1986 Nov;25(5):1001-6. doi: 10.1016/0091-3057(86)90077-8.
The plasma concentrations of morphine and glucose, the body weight, and the severity of the naloxone-precipitated withdrawal syndrome were studied in female rats in which morphine dependence was induced by administration of the opiate, with or without sucrose, in their drinking water. It was found that sucrose encouraged the animals to consume more morphine and that the initial plasma concentrations of the opiate, as well as the rate of development of physical dependence, were higher than the group not given sucrose. Plasma glucose concentrations, maximum plasma morphine levels and the maximum severity of the naloxone-precipitated withdrawal syndrome were, however, not significantly different between the two groups. The findings suggest that both regimens of administering the opiate in drinking fluid are effective in inducing morphine dependence in rats; the addition of sucrose tends to speed up the development of physical dependence, probably by increasing intake of the opiate through consuming more sucrose solution.
对雌性大鼠进行了研究，这些大鼠通过在饮用水中给予阿片类药物（有或没有蔗糖）诱导吗啡依赖，研究了吗啡和葡萄糖的血浆浓度、体重以及纳洛酮诱发的戒断综合征的严重程度。结果发现，蔗糖促使动物摄入更多吗啡，且阿片类药物的初始血浆浓度以及身体依赖的发展速度均高于未给予蔗糖的组。然而，两组之间的血浆葡萄糖浓度、血浆吗啡最高水平以及纳洛酮诱发的戒断综合征的最大严重程度并无显著差异。研究结果表明，在饮水中给予阿片类药物的两种方案在诱导大鼠吗啡依赖方面均有效；添加蔗糖可能通过消耗更多蔗糖溶液增加阿片类药物的摄入量，从而倾向于加速身体依赖的发展。
