Fletcher P J
Am J Physiol. 1984 Feb;246(2 Pt 2):H261-6. doi: 10.1152/ajpheart.1984.246.2.H261.
The baroreceptor heart rate reflex was studied in 26 renal hypertensive and 17 normotensive rabbits and in 13 rabbits after reversal of hypertension. Blood pressure and heart rate were varied by bolus injections of methoxamine or nitroglycerine in conscious rabbits, and a logistic sigmoid function was fitted to the pressure-heart rate data to estimate upper and lower heart rate plateaus, median blood pressure, and reflex sensitivity. In hypertensive rabbits, resetting of the blood pressure-heart rate curves to higher pressures was associated with reduced reflex sensitivity, increased lower heart rate plateau, and operating pressures significantly greater than the region of maximum reflex sensitivity, resulting in substantial attenuation of reflex bradycardia in response to hypertension. Reflex bradycardia after smoke inhalation was normal. Reversing the hypertension completely reversed the abnormalities in baroreflex control of heart rate. Renal hypertension in the rabbit produces functional changes that are completely reversible in the baroreceptor-heart rate reflex, probably in the afferent limb.
在26只肾性高血压兔、17只正常血压兔以及13只高血压逆转后的兔中研究了压力感受器心率反射。通过向清醒兔静脉推注甲氧明或硝酸甘油来改变血压和心率，并将逻辑S形函数拟合到压力-心率数据，以估计心率的上限和下限平台、平均血压以及反射敏感性。在高血压兔中，血压-心率曲线向更高压力的重置与反射敏感性降低、心率下限平台增加以及工作压力显著高于最大反射敏感性区域有关，导致对高血压的反射性心动过缓明显减弱。吸入烟雾后的反射性心动过缓正常。高血压的逆转完全纠正了压力感受器对心率控制的异常。兔的肾性高血压在压力感受器-心率反射中产生了可能在传入支的完全可逆的功能变化。
