注射醋酸甲羟孕酮和庚酸睾酮诱导少精子症期间雄性兔的生育力

Fertility of male rabbits during oligozoospermia induced by injections of medroxyprogesterone acetate and testosterone enanthate.

作者信息

Aribarg A

出版信息

Andrologia. 1983;15 Spec No:578-83. doi: 10.1111/j.1439-0272.1983.tb00219.x.

DOI:10.1111/j.1439-0272.1983.tb00219.x

Abstract

Spermatogenesis of male rabbits was completely suppressed by weekly injection of medroxyprogesterone acetate (10 mg) combined with testosterone enanthate (5 mg) for 6 weeks. However, the fertility of the medicated animals was not abolished during the induced oligozoospermia objectively determining by artificial insemination. Besides reduction in sperm density, the drugs did not cause any significant change in neither sperm motility nor morphology. If the combination of medroxyprogesterone acetate and testosterone enanthate is to be effectively used as a male contraceptive it must be given at such a dose that azoospermia is induced and continuously maintained with some consequent undesirable side effects.

摘要

每周注射醋酸甲羟孕酮（10毫克）联合庚酸睾酮（5毫克），持续6周，可完全抑制雄兔的精子发生。然而，通过人工授精客观测定，在诱导少精子症期间，用药动物的生育能力并未消除。除了精子密度降低外，这些药物对精子活力和形态均未引起任何显著变化。如果醋酸甲羟孕酮和庚酸睾酮的组合要有效地用作男性避孕药，必须给予能诱导并持续维持无精子症的剂量，这会带来一些不良副作用。