Hofmann G O, Land W, Weiss E P, Hammer C, Permanetter W, Brendel W
Eur Surg Res. 1984;16(1):40-6. doi: 10.1159/000128387.
Modification of the immune response towards the generation of suppressor T cells can be attained using experimental designs promoting immunological feedback mechanisms. Those studies have been carried out in defined inbred animal systems. With respect to the great importance for organ transplantation, an in vivo model using larger outbred animals was developed in order to study such feedback reactions. The following experimental design was used: (1) allogeneic spleen transplantation in the dog; (2) autologous retransplantation of this spleen together with an allogeneic kidney transplantation to the former donor of the spleen after a period of 2-4 days. Although full immunological activity of the transplanted as well as the retransplanted spleen was demonstrated, rejection of the kidney occurred in a fashion identical to that observed in control animals.
利用促进免疫反馈机制的实验设计，可以实现对免疫反应的调节，使其朝着产生抑制性T细胞的方向发展。这些研究是在特定的近交动物系统中进行的。鉴于器官移植的重要性，为了研究这种反馈反应，开发了一种使用较大的远交动物的体内模型。采用了以下实验设计：（1）在犬类中进行同种异体脾移植；（2）在2-4天后，将该脾脏与同种异体肾移植一起自体再移植到脾脏的前供体。尽管移植的脾脏和再移植的脾脏都表现出完全的免疫活性，但肾脏的排斥反应与对照动物中观察到的情况相同。
