真核生物鞭毛的遗传与生化剖析
Genetic and biochemical dissection of the eucaryotic flagellum.
作者信息
Luck D J
出版信息
J Cell Biol. 1984 Mar;98(3):789-94. doi: 10.1083/jcb.98.3.789.
Abstract
The axoneme is the basic functional unit of the eucaryotic flagellum. Periodic structures appended to its 9+2 microtubule core are responsible for generation of flagellar bending. An account of biochemical and genetic studies of flagellar-defective mutants of Chlamydomonas reinhardtii is presented. These studies provide insights into the complex molecular composition of the appended structures, their mode of assembly, and the way in which they interact to modulate flagellar function.
摘要
轴丝是真核生物鞭毛的基本功能单位。附着在其9+2微管核心上的周期性结构负责鞭毛弯曲的产生。本文介绍了莱茵衣藻鞭毛缺陷突变体的生化和遗传学研究。这些研究为附属结构的复杂分子组成、它们的组装方式以及它们相互作用以调节鞭毛功能的方式提供了见解。
相似文献
1
Genetic and biochemical dissection of the eucaryotic flagellum.真核生物鞭毛的遗传与生化剖析
J Cell Biol. 1984 Mar;98(3):789-94. doi: 10.1083/jcb.98.3.789.
2
Suppressor mutations in Chlamydomonas reveal a regulatory mechanism for Flagellar function.衣藻中的抑制突变揭示了鞭毛功能的调控机制。
Cell. 1982 Jan;28(1):115-24. doi: 10.1016/0092-8674(82)90381-6.
3
Regulation of dynein-driven microtubule sliding by the radial spokes in flagella.鞭毛中径向辐条对动力蛋白驱动的微管滑动的调节。
Science. 1992 Sep 11;257(5076):1557-9. doi: 10.1126/science.1387971.
4
Mutations at twelve independent loci result in absence of outer dynein arms in Chylamydomonas reinhardtii.在莱茵衣藻中，十二个独立位点的突变导致外动力蛋白臂缺失。
J Cell Biol. 1988 Dec;107(6 Pt 1):2253-8. doi: 10.1083/jcb.107.6.2253.
5
A motility in the eukaryotic flagellum unrelated to flagellar beating.真核生物鞭毛中一种与鞭毛摆动无关的运动。
Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5519-23. doi: 10.1073/pnas.90.12.5519.
6
Temperature-sensitive mutations affecting flagellar assembly and function in Chlamydomonas reinhardtii.影响莱茵衣藻鞭毛组装和功能的温度敏感突变
J Cell Biol. 1977 Jan;72(1):67-85. doi: 10.1083/jcb.72.1.67.
7
Evidence for axonemal distortion during the flagellar beat of Chlamydomonas.衣藻鞭毛摆动过程中轴丝变形的证据。
Cell Motil Cytoskeleton. 2007 Aug;64(8):580-9. doi: 10.1002/cm.20205.
8
A regulatory mechanism for flagellar function is revealed by suppressor analysis in Chlamydomonas.衣藻中的抑制子分析揭示了鞭毛功能的一种调控机制。
Prog Clin Biol Res. 1982;80:159-64. doi: 10.1002/cm.970020730.
9
Beat frequency difference between the two flagella of Chlamydomonas depends on the attachment site of outer dynein arms on the outer-doublet microtubules.衣藻两条鞭毛之间的拍频差异取决于外动力蛋白臂在外双联体微管上的附着位点。
Cell Motil Cytoskeleton. 1997;36(1):68-75. doi: 10.1002/(SICI)1097-0169(1997)36:1<68::AID-CM6>3.0.CO;2-D.
10
Exploring the function of inner and outer dynein arms with Chlamydomonas mutants.利用衣藻突变体探索内、外动力蛋白臂的功能。
Cell Motil Cytoskeleton. 1995;32(2):98-102. doi: 10.1002/cm.970320205.
引用本文的文献
1
The Ultrastructure and Composition of Bovine Spermatozoa.牛精子的超微结构与组成
Adv Anat Embryol Cell Biol. 2025;240:1-64. doi: 10.1007/978-3-031-70126-9_1.
2
KIF2C is essential for meiosis and manchette dynamics in male mice.KIF2C对雄性小鼠的减数分裂和精子尾部线粒体鞘动态变化至关重要。
Front Cell Dev Biol. 2025 Mar 27;13:1523593. doi: 10.3389/fcell.2025.1523593. eCollection 2025.
3
TCTEX1D2 is essential for sperm flagellum formation in mice.TCTEX1D2对小鼠精子鞭毛的形成至关重要。
Sci Rep. 2025 Jan 18;15(1):2413. doi: 10.1038/s41598-024-83424-1.
4
Integrative modeling reveals the molecular architecture of the intraflagellar transport A (IFT-A) complex.整合建模揭示了中间纤维运输 A (IFT-A) 复合物的分子结构。
Elife. 2022 Nov 8;11:e81977. doi: 10.7554/eLife.81977.
5
Hedgehog Morphogens Act as Growth Factors Critical to Pre- and Postnatal Cardiac Development and Maturation: How Primary Cilia Mediate Their Signal Transduction.刺猬信号蛋白作为生长因子，对心脏发育和成熟的先天和后天都至关重要：初级纤毛如何介导其信号转导。
Cells. 2022 Jun 9;11(12):1879. doi: 10.3390/cells11121879.
6
Systematic characterization of gene function in the photosynthetic alga Chlamydomonas reinhardtii.系统表征光合藻类莱茵衣藻中的基因功能。
Nat Genet. 2022 May;54(5):705-714. doi: 10.1038/s41588-022-01052-9. Epub 2022 May 5.
7
Microtubule organelles in Giardia.贾第虫中的微管细胞器。
Adv Parasitol. 2020;107:25-96. doi: 10.1016/bs.apar.2019.11.001. Epub 2020 Feb 5.
8
Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice.Nexin-Dynein 调节复合物组件 DRC7 而非 FBXL13 对于精子鞭毛形成和雄性小鼠生育力是必需的。
PLoS Genet. 2020 Jan 21;16(1):e1008585. doi: 10.1371/journal.pgen.1008585. eCollection 2020 Jan.
9
CILIA: before and after.纤毛：前后对比。
Cilia. 2017 Mar 8;6:1. doi: 10.1186/s13630-017-0046-8. eCollection 2017.
10
Alternative cytoskeletal landscapes: cytoskeletal novelty and evolution in basal excavate protists.替代细胞骨架景观：基础挖掘原生动物中的细胞骨架新颖性和进化。
Curr Opin Cell Biol. 2013 Feb;25(1):134-41. doi: 10.1016/j.ceb.2012.11.005. Epub 2013 Jan 8.
本文引用的文献
1
Linkage maps in Chlamydomonas reinhardi.莱茵衣藻的连锁图谱。
Genetics. 1962 May;47(5):531-43. doi: 10.1093/genetics/47.5.531.
2
Mutants of Chlamydomonas moewusii with impaired motility.运动能力受损的莱茵衣藻突变体。
J Gen Microbiol. 1954 Dec;11(3):358-63. doi: 10.1099/00221287-11-3-358.
3
Radial spokes of Chlamydomonas flagella: genetic analysis of assembly and function.衣藻鞭毛的辐条：组装与功能的遗传分析
J Cell Biol. 1981 Jan;88(1):80-8. doi: 10.1083/jcb.88.1.80.
4
Uniflagellar mutants of Chlamydomonas: evidence for the role of basal bodies in transmission of positional information.衣藻的单鞭毛突变体：关于基体在位置信息传递中作用的证据
Cell. 1982 Jul;29(3):745-53. doi: 10.1016/0092-8674(82)90436-6.
5
Analysis of the movement of Chlamydomonas flagella:" the function of the radial-spoke system is revealed by comparison of wild-type and mutant flagella.衣藻鞭毛运动分析：“通过野生型和突变型鞭毛的比较揭示了辐条系统的功能。”
J Cell Biol. 1982 Mar;92(3):722-32. doi: 10.1083/jcb.92.3.722.
6
Central-pair microtubular complex of Chlamydomonas flagella: polypeptide composition as revealed by analysis of mutants.衣藻鞭毛的中央微管复合体：通过突变体分析揭示的多肽组成
J Cell Biol. 1981 Oct;91(1):69-76. doi: 10.1083/jcb.91.1.69.
7
Genetic dissection of the central pair microtubules of the flagella of Chlamydomonas reinhardtii.莱茵衣藻鞭毛中央微管对的遗传剖析。
J Cell Biol. 1984 Jan;98(1):229-36. doi: 10.1083/jcb.98.1.229.
8
Suppressor mutations in Chlamydomonas reveal a regulatory mechanism for Flagellar function.衣藻中的抑制突变揭示了鞭毛功能的调控机制。
Cell. 1982 Jan;28(1):115-24. doi: 10.1016/0092-8674(82)90381-6.
9
Inner arm dyneins from flagella of Chlamydomonas reinhardtii.莱茵衣藻鞭毛的内臂动力蛋白。
Cell. 1981 Dec;27(2 Pt 1):331-40. doi: 10.1016/0092-8674(81)90416-5.
10
Structure of the dynein-1 outer arm in sea urchin sperm flagella. I. Analysis by separation of subunits.海胆精子鞭毛中动力蛋白-1外臂的结构。I. 亚基分离分析
J Biol Chem. 1982 Jan 10;257(1):508-15.
Zotero 插件